Publications

Selected publications

2020

Braun LJ, Stegmeyer R, Schäfer K, Volkery S, Currie SM, Kempe B, Nottebaum AF, Vestweber D. Platelets docking to VWF prevent leaks during leukocyte extravasation by stimulating Tie-2. Blood, 2020, May 5:blood.2019003442. doi: 10.1182/blood.

Samus M, Li YT, Sorokin L, Rottner K, Vestweber D. Actin-binding protein cortactin promotes pathogenesis of experimental autoimmune encephalomyelitis by supporting leukocyte infiltration into the central nervous system. J Neurosci., 2020, 40:1389-1404

Duong CN, Nottebaum AF, Butz S, Volkery S, Zeuschner D, Stehling M, Vestweber D. Immediate lethality and lung specific blood coagulation upon interference with ESAM plus VE-cadherin. Arterioscler. Thromb. Vasc. Biol., 2020 40: 378-393

Owen-Woods C, Joulia R, Barkaway A, Rolas L, Ma B, Nottebaum AF, Arkill K, Girbl T, Golding M, Bates D, Vestweber D, Voisin M.-B., Nourshargh S. Local microvascular leakage promotes trafficking of activated neutrophils to emote organs in vivo. J. Clin. Invest., 2020; 130: 2301-2318

Rademakers T, Goedhart M, Hoogenboezem M, García Ponce A, van Rijssel J, Samus M, Schnoor M, Butz S, Huveneers S, Vestweber D, Nolte MA, Voermans C, van Buul JD. Hematopoietic stem and progenitor cells use podosoems to transcellularly cross the bone marrow endothelium. Haematologica 2020; Jan 23 doi: 10.3324/haematol.2018.

Bergerhausen L, Grosche J, Meißner J, Hecker C, Caliandro MF, Westerhausen C, Kamenac A, Rezaei M, Mörgelin M, Poschmann G, Vestweber D, Hanschmann EM, Eble JA. Extracellular redox regulation of 71 integrin-mediated cell migration is signaled via a dominant thiol-switch. Antioxidants 2020, Mar 10;9(3): 227. doi: 10.3390/antiox9030227.

Smith R, Ninchoji T, Gordon E, André H, Dejana E, Vestweber D, Kvanta A, Claesson-Welsh L. Vascular permeability in retinopathy is regulated by VEGFR2 Y949 signaling to VE-cadherin. eLife 2020 in press

Sheikh BN, Guhathakurta S, Tsang TH, Schwabenland M, Renschler G, Herquel B, Bhardwaj V, Holz H, Stehle T, Bondareva O, Aizarani N, Mossad O, Kretz O, Reichardt W, Chatterjee A, Braun LJ, Thevenon J, Sartelet H, Blank T, Grün D, von Elverfeldt D, Huber TB, Vestweber D, Avilov S, Prinz M, Buescher JM, Akhtar A. Neural metaboloic imbalance induced by MOF dysfunction triggers pericyte activation and breakdown of vasculature. Nat. Cell Biol. 2020 Jun 15 doi: 10.1038/s41556-020-0526-8. Online ahead of print.

2019

Thomson BR, Carota IA, Souma T, Soman S, Vestweber D, Quaggin SE. Targeting the vascular specific PTPRB protects against retinal ganglion cell loss in a pre-clinical model of glaucoma. eLIFE, Oct 17;8 pii:e48474 [Epub ahead of print]

Herich S, Schneider-Hohendorf T, Rohlmann A, Khaleghi Ghadiri M, Schulte-Mecklenbeck A, Zondler L, Janoschka C, Ostkamp P, RichterJ, Breuer J, Dimitrov S, Grauer OM, Klotz L, Gross CC, Stummer W, Missler M, Zarbock A, Vestweber D, Wiendl H, Schwab N. CCR5^high effector-memory cells perform CNS parenchymal immune surveillance in humans via Granzyme K-mediated transendothelial diapedesis. Brain, 142: 3411-3427.

Drexler HCA, Vockel M, Polaschegg C, Frye M, Peters K, Vestweber D. Vascular endothelial receptor tyrosine phosphatase: Identification of novel substrates related to junctions and a ternary complex with EphB4 and Tie-2. Mol. Cell Proteomics, 2019 Oct;18(10):2058-2077.

Li YT, Goswami D, Pacheco-Blanco M, Artz A, Vestweber D. Blood flow guides sequential support of neutrophil arrest and diapedesis by PILR-b1 and PILR-a. eLIFE, 2019 Aug 6;8. pii: e47642. doi: 10.7554/eLife.47642.

Braun LJ, Zinnhardt M, Vockel M, Drexler HC, Peters K, Vestweber D. VE-PTP inhibition stabilizes endothelial junctions by activating FGD5. EMBO Rep. 2019 Jul; 20(7) e47046

Carota IA, Kenig-Kozlovsky Y, Onay T, Scott R, Thomson BR, Souma T, Bartlett CS, Li Y, Procissi D, Ramirez V, Yamaguchi S, Tarjus A, Tanna CE, Li C, Eremina V, Vestweber D, Oladipupo SS, Breyer MD, Quaggin SE. Targeting VE-PTP phosphatase protects the kidney from diabetic injury. J. Exp. Med. 2019 216(4):936-949.

2018

Hägerling R, Hoppe E, Dierkes C, Stehling M, Makinen T, Butz S, Vestweber D, Kiefer F. Distinct roles of VE-cadherin for development and maintenance of specific lymph vessel beds. EMBO J. 37(22) pii: e98271. doi: 10.15252/embj.201798271. Epub 2018 Oct 8.

Reckzeh K, Kizilkaya H, Helbo AS, Alrich ME, Deslauriers AG, Grover A, Rapin N, Asmar F, Grønbæk K, Porse B, Borregaard N, Vestweber D, Nerlov C, Theilgaard-Mönch K. Human adult HSCs can be discriminated from lineage-committed HPCs by the expression of endomucin. Blood Adv. 2: 1628-1632

Samus M, Seelige R, Schäfer K, Sorokin L, Vestweber D. CD99L2 deficiency inhibits leukocyte entry into the central nervous system and ameliorates neuroinflammation. J. Leukoc. Biol. 104:787-797

Schwartz MA, Vestweber D, Simons M. A unifying concept in vascular health and disease. Science 360: 270-271

Souma T, Thomson B, Heinen S, Carota I, Yamaguchi S, Onay T, Liu P, Ghosh A, Li C, Eremina V, Hong YK, Economides A, Vestweber D, Peters K, Jin J, Quaggin S. Context-dependent functions of Angiopoietin 2 are determined by the endothelial phosphatase VEPTP. Proc. Natl. Acad. Sci. USA 115: 1298-1303

2017

Liu Y, Shen J, Fortmann SD, Wang J, Vestweber D, Campochiaro PA. Reversible Retinal Vessel Closure from VEGF-induced Leukostasis. JCI Insight 2017 Sep 21;2(18). pii: 95530. doi: 10.1172/jci.insight.95530. [Epub ahead of print]

Hägerling R, Drees D, Scherzinger A, Dierkes C, Martin-Almedina S, Butz S, Gordon K, Schäfers M, Hinrichs K, Ostergaard P, Vestweber D, Goerge T, Mansour S, Jiang X, Mortimer PS, Kiefer F. VIPAR, a diagnostic approach for 3D-histopathology applied to lymphatic malformations. JCI Insight 2017 Aug 17;2(16). pii: 93424. doi: 10.1172/jci.insight.93424. [Epub ahead of print]

Conway DE, Coon BG, Budatha M, Arsenovic PT, Orsenigo F, Wessel F, Zhang J, Zhuang Z, Dejana E, Vestweber D, Schwartz MA. VE-cadherin phosphorylation regulates endothelial fluid shear stress responses through the polarity protein LGN. Curr. Biol. 27:2219-2225

Takahashi K, Kim R, Lauhan C, Park Y, Nguyen NG, Vestweber D, Dominguez MG, Valenzuela DM, Murphy AJ, Yancopoulos GD, Gale NW, Takahashi T. Expression of receptor-type protein tyrosine phosphatase in developing and adult renal vasculature. PLoS One 12:e0177192

Döring Y, Noels H, van der Vorst EPC, Neideck C, Egea V, Drechsler M, Mandl M, Pawig L, Jansen Y, Schröder K, Bidzhekov K, Megens RTA, Theelen W, Klinkhammer BM, Boor P, Schurgers L, van Gorp R, Ries C, Kusters PJH, van der Wal A, Hackeng TM, Gäbel G, Brandes RP, Soehnlein O, Lutgens E, Vestweber D, Teupser D, Holdt LM, Rader DJ, Saleheen D, Weber C. Vascular CXCR4 limits atherosclerosis by maintaining arterial integrity: evidence from mouse and human studies. Circulation 136: 388-402

Haghayegh Jahromi N, Tardent H, Enzmann G, Deutsch U, Kawakami N, Bittner S, Vestweber D, Zipp F, Stein JV, Engelhardt B. A novel cervical spinal cord window preparation allows for two-photon imaging of T-cell intercations with the cervical spinal cord microvasculature during experimental autoimmune encephalomyelitis. Front. Immunol. 8:406

Goswami D, März S, Li YT, Artz A, Schäfer K, Seelige R, Pacheco-Blanco M, Jing D, Bixel MG, Araki M, Araki K, Yamamura K, Vestweber D. Endothelial CD99 supports arrest of mouse neutrophils in venules ad binds to neutrophil PILRs. Blood 129: 1811-1822

Bixel MG, Kusumbe AP, Ramasamy SK, Sivaraj KK, Butz S, Vestweber D, Adams RH. Flow dynamics and HSPC Homing in bone marrow microvessels. Cell Rep. 18:1804-1816

Song J, Zhang X, Buscher K, Wang Y, Wang H, Di Russo J, Li L, Lütke-Enking S, Zarbock A, Stadtmann A, Striewski P, Wirth B, Kuzmanov I, Wiendl H, Schulte D, Vestweber D, Sorokin L. Endothelial basement membrane laminin 511 contributes to endothelial junctional tightness and thereby inhbits leukocyte transmigration. Cell Rep. 18:1256-1269

Latasiewicz J, Artz A, Jing D, Blanco MP, Currie SM, Avila MV, Schnoor M, Vestweber D. HS1 deficiency impairs neutrophil recruitment in vivo and activation of the small GTPases Rac1 and Rap1. J. Leukoc. Biol. 101:1133-1142

Li J, Su Y, Xia W, Humphries M, Vestweber D, Cabanas C, Lu C, Springer TA. Conformational equilibria and intrinsic affinities define the landscape for activation of integrin a₅b₁. EMBO J. 36:629-645

2016

Kurz AR, Pruenster M, Rohwedder I, Ramadass M, Schäfer K, Harrison U, Gouveia G, Nussbaum C, Immler R, Wiessner JR, Margraf A, Lim DS, Walzog B, Dietzel S, Moser M, Klein C, Vestweber D, Haas R, Catz SD, Sperandio M. MST1-dependent vesicle trafficking regulates neutrophil transmigration through the vascular basement membrane.J Clin Invest. 126:4125-4139

García Ponce A, Citalán Madrid AF, Vargas Robles H, Chánez Paredes S, Nava P, Betanzos A, Zarbock A, Rottner K, Vestweber D, Schnoor M. Loss of cortactin causes endothelial barrier dysfunction via disturbed adrenomedullin contractility. Sci. Rep. 2016(6):29003

Su Y, Xia W, Li J, Walz T, Humphries MJ, Vestweber D, Cabañas C, Lu C, Springer TA. Relating conformation to function in integrin α5β1. Proc. Natl. Acad. Sci. U S A 113(27):E3872-81

Barreiro O, Cibrian D, Clemente C, Alvarez D, Moreno V, Valiente Í, Bernad A, Vestweber D, Arroyo AG, Martín P, von Andrian UH, Sánchez Madrid F. Pivotal role for skin transendothelial radio-resistant anti-inflammatory macrophages in tissue repair. Elife 5. pii: e15251. doi: 10.7554/eLife.15251

Artz A, Butz S, Vestweber D. GDF-15 inhibits integrin activation and mouse neutrophil recruitment through the ALK-5/TGF-βRII heterodimer. Blood 28(4):529-41

Li X, Padhan N, Sjöström EO, Roche FP, Testini C, Honkura N, Sáinz-Jaspeado M, Gordon E, Bentley K, Philippides A, Tolmachev V, Dejana E, Stan RV, Vestweber D, Ballmer-Hofer K, Betsholtz C, Pietras K, Jansson L, Claesson-Welsh L. VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread. Nat. Commun. 7:11017

2015

Frye M, Dierkes M, Küppers V, Vockel M, Tomm J, Zeuschner D, Roissant J, Zarbock A, Koh GY, Peters K, Nottebaum AF, Vestweber D. (2015) Interfering with VE-PTP stabilizes endothelial junctions in vivo via Tie-2 in the absence of VE-cadherin. J. Exp. Med. 212:2267-87

Hillgruber C, Pöppelmann B, Weishaupt C, Steingräber AK, Wessel F, Berdel WE, Gessner JE, Ho-Tin-Noé B, Vestweber D*, Goerge T*. (2015) Blocking neutrophil diapedesis prevents hemorrhage during thrombocytopenia. J. Exp. Med. 212:1255-66 *D.V. and T.G. are shared corresponding authors

Vestweber D. (2015) How leukocytes cross the vascular endothelium. Nat. Rev. Immunol. 15: 692-704

Yamamoto H, Ehling M, Kato K, Kenichi Kanai K, van Lessen M, Frye M, Zeuschner D, Nakayama M, Vestweber D, Adams RH. (2015) Integrin β1 controls VE-cadherin localization and blood vessel stability. Nat. Commun. 6:6429 doi: 10.1038/ncomms7429.

Pruenster M, Kurz ARM, Chung K-J, Cao-Ehlker X, Stephanie, Bieber S, Nussbaum CF, Bierschenk S, Eggersmann TK, Rohwedder I, Heinig K, Immler R, Moser M, Koedel U, Gran S, McEver RP, Vestweber D, Verschoor A, Leandersson T, Chavakis T, Roth J, Vogl T, Sperandio M. (2015) Extracellular MRP8/14 is a regulator of b2 integrin dependent neutrophil slow rolling and adhesion in vivo. Nat. Commun. 6:6915 doi: 10.1038/ncomms7915

Anderson H, Patch TC, Reddy PN, Hagedorn EJ, Kim PG, Soltis KA, Chen MJ, Tamplin OJ, Frye M, MacLean GA, Hübner K, Bauer DE, Kanki JP, Vogin G, Huston NC, Nguyen M, Fujiwara Y, Paw BH, Vestweber D, Zon LI, Orkin SH, Daley GQ, Shah DI. (2015) Hematopoetic stem cells develop in the absence of endothelial cadherin 5 expression. Blood 126:2811-20

Vestweber D. (2015) Cadherins in tissue architecture and disease. J. Mol. Med. (Berl). 93:5-11

2014

Shen J, Frye M, Lee BL, Reinardy JL, McClung JM, Ding K, Kojima M, Xia H, Seidel C, Lima e Silva R, Dong A, Hackett SF, Wang J, Howard BW, Vestweber D, Kontos CD, Peters KG, Campochiaro PA. (2014) Targeting VE-PTP activates TIE2 and stabilizes the ocular vasculature. J. Clin. Invest. 124:4564-76

Schneider-Hohendorf T, Rossaint J, Mohan H, Böning D, Breuer J, Kuhlmann T, Gross CC, Flanagan K, Sorokin L, Vestweber D, Zarbock A, Schwab N, Wiendl H. (2014) VLA-4 blockade promotes differential routes into human CNS involving PSGL-1 rolling of T cells and MCAM-adhesion of TH17 cells. J. Exp. Med. 211:1833-46

Rocha SF, Schiller M, Jing D, Li H, Butz S, Vestweber D, Biljes D, Drexler HC, Nieminen-Kelhä M, Vajkoczy P, Adams S, Benedito R, Adams RH. (2014) Esm1 modulates endothelial tip cell behavior and vascular permeability by enhancing VEGF bioavailability. Circ. Res. 115:581-90

Abadier M, Jahromi NH, Cardoso-Alves L, Boscacci R, Vestweber D, Barnum S, Deutsch U, Engelhardt B, Lyck R. (2014) Cell surface levels of endothelial ICAM-1 influence the transcellular or paracellular T-cell diapedesis across the blood-brain barrier. Eur. J. Immunol. 45:1043-1058

Vestweber D, Wessel F, Nottebaum AF. (2014) Similarities and differences in the regulationof leukocyte extravasation and vascular permeability. Semin. Immunopathol. 36:177-92

Dartsch N, Schulte D, Hägerling R, Kiefer F, Vestweber D. Fusing VE-cadherin to a-catenin impairs fetal liver hematopoiesis and lymph, but not blood vessel formation. Mol. Cell. Biol. (2014) in press

Bentley K, Franco CA, Philippides A, Blanco R, Dierkes M, Gebala V, Stanchi F, Jones M, Aspalter IM, Cagna G, Kutschera S, Claesson-Welsh L, Vestweber D, Gerhardt H. (2014) The role of differential VE-cadherin dynamics in cell rearrangement during angiogenesis. Nat. Cell Biol. in press

Wessel F, Winderlich M, Holm M, Frye M, Rivera-Galdos R, Vockel M, Linnepe R, Ipe U, Stadtmann A, Zarbock A, Nottebaum A, Vestweber D. (2014) Leukocyte extravasation and vascular permeability are each controlled in vivo by a different tyrosine residue of VE-cadherin. Nat. Immunol. 15:223-230

Kraus H, Kaiser S, Aumann K, Bönelt P, Salzer U, Vestweber D, Erlacher M, Kunze M, burger M, Pieper K, Sic H, Rolink A, Eibel H, Rizzi, M. (2014) A feeder free differentiation system identifies autonomously proliferating B cell precursors in human bone marrow. J. Immunol. 192:1044-1054

Gorina R, Lyck R, Vestweber D, Engelhardt B. (2014) β2 Integrin-Mediated Crawling on Endothelial ICAM-1 and ICAM-2 Is a Prerequisite for Transcellular Neutrophil Diapedesis across the Inflamed Blood-Brain Barrier. J. Immunol. 192:324-337

2013

Sehnert B, Burkhardt H, Wessels J, Vestweber D, Zwerina J, Nimmerjahn F, Schett G, Dübel S, Voll RE. (2013) An NF-κB inhibitor targeted to activated endothelium demonstrates a critical role of endothelial NF-κB in immune-mediated diseases. PNAS 110:16556-16561

Vockel M, Vestweber D. (2013) How T cells trigger the dissociation of the endothelial receptor phosphatase VE-PTP from VE-cadherin. Blood 122: 2512-2522

Hillgruber C, Steingräber AK, Pöppelmann B, Denis CV, Ware J, Vestweber D, Nieswandt B, Schneider SW, Goerge T. (2013) Blocking Von Willebrand Factor for treatment of cutaneous inflammation. J. Invest. Dermatol. 134:77-86

Rossaint J, Vestweber D, Zarbock A (2013). GDF-15 prevents platelet integrin activation and thrombus formation. J. Thromb. Haemost. 11:335-344

Nakayama M, Nakayama A, Van Lessen M, Yamamoto H, Hoffmann S, Drexler HCA, Itoh N, Hirose T, Breier G, Vestweber D, Cooper JA, Ohno S, Kaibuchi K, Adams RH. (2013) Spatial regulation of VEGF receptor endocytosis in angiogenesis. Nat. Cell Biol. 15:249-60.

Seelige R, Natsch C, März S, Jing D, Frye M, Butz S, Vestweber D (2013). Endothelial specific gene ablation of CD99L2 impairs leukocyte extravasation in vivo. J. Immunol. 190:892-896

Hayashi M, Majumdar A, Li X, Adler J, Sun Z, Vertuani S, Hellberg C, Mellberg S, Koch S, Dimberg A, Young Koh GY, Dejana E, Belting H-G, Affolter M, Thurston G, Holmgren L, Vestweber D, Claesson-Welsh L. (2013) VE-PTP regulates VEGFR2 stalk cell activity in a Tie2-dependent manner to establish endothelial cell polarity and lumen formation. Nat. Commun. 4:1672.

Dejana E, Vestweber D. (2013) The Role of VE-cadherin in Vascular Morphogenesis and Permeability Control. Prog. Mol. Biol. Transl. Sci. 116:119-44

2012

Gaengel K, Niaudet C, Hagikura K, Siemsen BL, Muhl L, Hofmann JJ, Ebarasi L, Nyström S, Rymo S, Chen LL, Pang MF, Jin Y, Raschperger E, Roswall P, Schulte D, Benedito R, Larsson J, Hellström M, Fuxe J, Uhlén P, Adams R, Jakobsson L, Majumdar A, Vestweber D, Uv A, Betsholtz C (2012). The sphingosine-1-phosphate receptor S1PR1 restricts sprouting angiogenesis by regulating the interplay between VE-cadherin and VEGF-R2. Dev. Cell, 23:587-99

Vestweber D. (2012) Novel insights into leukocyte extravasation.Curr. Opin. Hematol. 19: 212-217

Vestweber D. (2012) Relevance of endothelial junctions in leukocyte extravasation and vascular permeability. Ann. N. Y. Acad. Sci. 1257:184-92

A. Zarbock, T Kempf , K.C. Wollert and Vestweber D. (2012) Leukocyte integrin activation and deactivation: novel mechanisms of balancing inflammation. J. Mol. Med. (Berl). 90:353-359

2011

A. Broermann, M. Winderlich, H. Block, M. Frye, J. Rossaint, A. Zarbock, G. Cagna, R. Linnepe, D. Schulte, A.F. Nottebaum and Vestweber D. (2011) Dissociation of VE-PTP from VE-cadherin is required for leukocyte extravasation and for VEGF-induced vascular permeability in vivo. J. Exp. Med. 208:2393-2401

D. Schulte, V. Küppers, N. Dartsch, A. Broermann, H. Li, A. Zarbock, O. Kamenyeva, F. Kiefer, A. Khandoga, S. Massberg and Vestweber D. (2011) Stabilizing the VE-cadherin-catenin complex blocks leukocyte extravasation and vascular permeability. EMBO J. 30:4157-7410

M. Schnoor, F.P.L. Lai, A. Zarbock, R. Kläver, C. Polaschegg, D. Schulte, H.A. Weich, J.M. Oelkers, K. Rottner and Vestweber, D. (2011) Cortactin deficiency is associated with reduced neutrophil recruitment but increased vascular permeability in vivo. J. Exp. Med. 208:1721-1735

T. Kempf, A. Zarbock, C. Widera, S. Butz, A. Stadtmann, J. Rossaint, M. Bolomini-Vittori, M. Korf-Klingebiel, L.C. Napp, B. Hansen, A. Kanwischer, U. Bavendiek, G. Beutel, M. Hapke, M.G. Sauer, C. Laudanna, N. Hogg, D. Vestweber* and K.C. Wollert* (2011) GDF15, an inhibitor of leukocyte integrin activation required for survival after myocardial infarction. Nat. Med. 17:581-588
*D.V. and K.C.W. are shared corresponding authors

2010

M.G. Bixel, H. Li, B. Petri, A.G. Khandoga, A. Khandoga, A. Zarbock, K. Wolburg-Buchholz, H. Wolburg, L. Sorokin, D. Zeuschner, S. Maerz, S. Butz, F. Krombach and D. Vestweber (2010) CD99 and CD99L2 act at the same site as, but independently of, PECAM-1 during leukocyte diapedesis. Blood 116:1172-1184

B. Petri, A. Broermann, H. Li, A.G. Khandoga, A. Zarbock, F. Krombach, T. Goerge, S.W. Schneider, C. Jones, B. Nieswandt, M.K. Wild and D. Vestweber (2010) Von Willebrand factor promotes leukocyte extravasation. Blood 116:4712-4719

2009

M. Winderlich, L. Keller, G. Cagna, A. Broermann, O. Kamenyeva, F. Kiefer, U. Deutsch, A. Nottebaum and D. Vestweber (2009) VE-PTP controls blood vessel development by balancing Tie-2 activity. J. Cell Biol. 185:657-671

C. Wu, F. Ivars, P. Anderson, R. Hallmann, D. Vestweber, P. Nilsson, H. Robenek, K. Tryggvason, J. Song, E. Korpos, K. Loser, S. Beissert, E. Georges-Labouesse and L. Sorokin (2009) Endothelial Basement Membrane Laminin α5 Selectively Inhibits T Lymphocyte Extravasation Into the Brain. Nat. Med. 15:519-527

A. Tanne, B. Ma, F. Boudou, L. Tailleux, H. Botella, E. Badell, F. Levillain, M.E. Taylor, K. Drickamer, J. Nigou, K.M. Dobos, G. Puzo, D. Vestweber, M.K. Wild, M. Marcinko, P. Sobieszczuk, L. Stewart, D. Lebus, B. Gicquel and O.A. Neyrolles (2009) murine DC-SIGN homologue contributes to early host defense against Mycobacterium tuberculosis. J. Exp. Med. 206:2205-2220

T. Yokota, K. Oritani, S. Butz, K. Kokame, P.W. Kincade, T. Miyata, D. Vestweber and Y. Kanakura (2009) The endothelial antigen ESAM marks primitive hematopoietic progenitors throughout life in mice.Blood 113: 2914-2923

A.G. Ooi, H. Karsunky, R. Majeti, S. Butz, D. Vestweber, T. Ishida, T. Quertermous, I.L. Weissman and E.C. Forsberg (2009) The Adhesion Molecule ESAM1 is A Novel Hematopoietic Stem Cell Marker. Stem Cells 27:653-661

2008

A.F. Nottebaum, G. Cagna, M. Winderlich, A.C. Gamp, R. Linnepe, C. Polaschegg, K. Filippova, R. Lyck, B. Engelhardt, O. Kamenyeva, M.G. Bixel, S. Butz and D. Vestweber (2008) VE-PTP maintains the endothelial barrier via plakoglobin and becomes dissociated from VE-cadherin by leukocytes and by VEGF. J. Exp. Med. 205: 2929-2945

D. Frommhold, A. Ludwig, M.G. Bixel, A. Zarbock, I. Babushkina, M. Weissinger, S. Cauwenberghs, L.G. Ellies, J.D. Marth, A.G. Beck-Sickinger, M. Sixt, B. Lange-Sperandio, A. Zernecke, E. Brandt, C. Weber, D. Vestweber, K. Ley and M. Sperandio (2008) Sialyltransferase ST3Gal-IV controls CXCR2-mediated firm leukocyte arrest during inflammation. J. Exp. Med. 205:1435-1446

P. Saharinen, L. Eklund, J. Miettinen, R. Wirkkala, A. Anisimov, M. Winderlich, A. Nottebaum, D. Vestweber, U. Deutsch, G.Y. Koh, B.R. Olsen and K. Alitalo (2008) Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts. Nat Cell Biol. 10:527-537

P.Turowski, R. Martinelli, R. Crawford, D. Wateridge, A.-P. Papagiorgiou, M.G. Lampugnani, A.C. Gamp, D. Vestweber, P. Adamson, E. Dejana and J. Greenwood (2008) Phosphorylation of Vascular Endothelial Cadherin Controls Lymphocyte Emigration. J. Cell Sci. 121: 29-37

2007

M.G. Bixel, B. Petri, A.G. Khandoga, A. Khandoga, K. Wolburg-Buchholz, H. Wolburg, S. Marz, F. Krombach and D. Vestweber (2007) A CD99-related antigen on endothelial cells mediates neutrophil, but not lymphocyte extravasation. Blood 109: 5327-5336

A. Hidalgo, A.J. Peired, M. Wild, D. Vestweber and P.S. Frenette (2007) Complete identification of E-selectin ligand activity on neutrophils reveals a dynamic interplay and distinct functions of PSGL-1, ESL-1 and CD44. Immunity 26: 477-489

P. Baluk, J. Fuxe, H. Hashizume, T. Romano, E. Lashnits, S. Butz, D. Vestweber, M. Corada, C. Molendini, E. Dejana and D.M. McDonald (2007) Functionally specialized junctions between endothelial cells of lymphatic vessels. J. Exp. Med. 204: 2349-2362

2006

F. Wegmann, B. Petri, A.G. Khandoga, C. Moser, A. Khandoga, S. Volkery, H. Li, I. Nasdala, O. Brandau, R. Fässler, S. Butz, F. Krombach and D. Vestweber (2006) ESAM supports neutrophil extravasation, activation of Rho and VEGF-induced vascular permeability. J. Exp. Med. 203:1671-1677

S. Baumer, L. Keller, A. Holtmann, R. Funke, B. August, A. Gamp, H. Wolburg, K. Wolburg-Buchholz, U. Deutsch and D. Vestweber (2006) Vascular endothelial cell specific phospho-tyrosine phosphatase (VE-PTP) activity is required for blood vessel development. Blood 107:4754-4762

2005

U. Baumeister, R. Funke, K. Ebnet, H. Vorschmitt, S. Koch and D. Vestweber (2005) Association of Csk to VE-cadherin and inhibition of cell proliferation. EMBO J. 24:1686-1695

A. Matsubara, A. Iwama, Y. Yamada, S. Yamazaki, C. Furuta, R. Hirasawa, Y. Morita, M. Osawa, T. Motohashi, K. Eto, H. Ema, T. Kitamura, D. Vestweber and H. Nakauchi (2005) Expression of Endomucin, a CD34-like sialomucin, marks definitive hematopoietic stem cells from their development through life. J. Exp. Med. 202:1483-1492

A.A. Dorner, F. Wegmann, S. Butz, K. Wolburg-Buchholz, H. Wolburg, A. Mack, I. Nasdala, B. August, J. Westermann, F.G. Rathjen and D. Vestweber (2005) Coxsackievirus-Adenovirus-Receptor (CAR) is essential for early embryonic cardiac development. J. Cell Sci. 118:3509-3521

2004

G. Bixel, S. Kloep, S. Butz, B. Petri, B. Engelhardt and D. Vestweber (2004) Mouse CD99 participates in T cell recruitment into inflamed skin. Blood 104:3205-3213

2003

P. Vajkoczy, S. Blum, M. Lamparter, R. Mailhammer, R. Erber, B. Engelhardt, D. Vestweber and A. K. Hatzopoulos (2003) Multistep nature of microvascular recruitment of ex vivo expanded embryonic endothelial progenitor cells during tumor angiogenesis. J. Exp. Med. 197:1755-1765

2002

R. Nawroth, G. Poell, A. Ranft, S. Kloep, U. Samulowitz, G. Fachinger, M. Golding, D.T. Shima, U. Deutsch, and D. Vestweber (2002) VE-PTP and VE-cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts. EMBO J. 21: 4885-4895

2001

K. Lühn, M.K. Wild, M. Eckhardt, R. Gerardy-Schahn and D. Vestweber (2001) The defective gene in leukocyte adhesion deficiency II codes for a GDP-fucose transporter. Nat. Genet. 28:69-72

K. Ebnet, A. Suzuki, Y. Horikoshi, T. Hirose, M.-K. Meyer-zu-Brickwedde, S. Ohno and D. Vestweber (2001) The cell polarity protein ASIP/PAR-3 directly associates with Junctional Adhesion Molecule (JAM). EMBO J. 20: 3738-3748 (2001)

2000

W. Baumgartner, P. Hinterdorfer, W. Ness, A. Raab, D. Vestweber, H. Schindler, and D. Drenckhahn (2000) Cadherin interaction probed by atomic force microscopy. Proc. Natl. Acad. Sci. USA 97:4005-4010

1999

T. Marquardt, K. Lühn, G. Srikrishna, H.H. Freeze, E. Harms, and D. Vestweber (1999) Correction of Leukocyte Adhesion Deficiency Type II with oral fucose. Blood 94:3976-3985

S.M. Morgan, U. Samulowitz, L. Darley, D.L. Simmons, and D. Vestweber (1999) Biochemical characterization and molecular cloning of a novel endothelial specific sialomucin. Blood 93: 165-175

1998

T. Moll, E. Dejana, and D. Vestweber (1998) In vitro degradation of endothelial catenins by a neutrophil protease. J. Cell Biol. 140:403-407

J. Alferink, A. Tafuri, D. Vestweber, R. Hallmann, G.J. Hämmerling, and B. Arnold (1998) Control of neonatal tolerance to tissue-antigens by peripheral T cell trafficking. Science 282: 1338-1341

1997

F. Austrup, D. Vestweber, E. Borges, M. Löhning, R. Bräuer, R. Hallmann, A. Scheffold, A. Radbruch, and A. Hamann (1997) P- and E-selectin mediate recruitment of T helper 1 but not of T helper 2 cells into inflamed tissues. Nature 385, 81-83

O. Zöllner, M.C. Lenter, J.E. Blanks, E. Borges, M. Steegmaier, H.-G. Zerwes, and D. Vestweber (1997) L-selectin from human but not from mouse neutrophils binds directly to E-selectin. J. Cell Biol. 136, 707-715

E. Borges, W. Tietz, M. Steegmaier, T. Moll, R. Hallmann, A. Hamann, and D. Vestweber (1997) PSGL-1 on T helper 1 but not on T helper 2 cell binds to P-selectin and supports migration into inflamed skin. J. Exp. Med. 185: 573-578

E. Borges, R. Eytner, T. Moll, M. Steegmaier, MA Campbell, K. Ley, H. Mossmann, and D. Vestweber (1997) The P-selectin glycoprotein ligand-1 is important for recruitment of neutrophils into inflamed mouse peritoneum. Blood 90: 1934-1942

M. Steegmaier, E. Borges, J. Berger, H. Schwarz, and D. Vestweber (1997) The E-selectin ligand ESL-1 is located in the Golgi as well as on microvilli on the cell surface. J. Cell Science. 110: 687-694

1996

O. Zöllner, and D. Vestweber (1996) The E-selectin Ligand-1 is selectively activated in CHO cells by the α(1,3)-Fucosyltransferase IV and VII. J. Biol. Chem. 271: 33002-33008

E.J. Kunkel, U. Jung, D.C. Bullard, K.E. Norman, B.A. Wolitzky, D. Vestweber, A.L. Beaudet and K. Ley (1996) Absence of Trauma-induced leukocyte rolling in mice deficient in both P-selectin and ICAM-1. J. Exp. Med. 183: 57-65

G. Breier, F. Breviario, L. Caveda, R. Berthier, H. Schnürch, U. Gotsch, D. Vestweber, W. Risau and E. Dejana (1996) Molecular cloning and expression of murine Vascular Endothelial Cadherin in early stage development of cardiovascular system. Blood 87: 630-641

1995

M. Steegmaier, A. Levinovitz, S. Isenmann, E. Borges, M. Lenter, H. Kocher, B. Kleuser and D. Vestweber (1995) The E-selectin-ligand ESL-1 is a variant of a receptor for fibroblast growth factor. Nature373: 615-620

K. Ley, D. Bullard, M.L. Arbones, R. Bosse, D. Vestweber, T. Tedder and A. Beaudet (1995) Sequential contribution of P- and L-selectin to leukocyte rolling in vivo. J. Exp. Med. 181: 669-675

1994

R. Bosse and D. Vestweber (1994) Only blocking of L- and P-selectin completely blocks neutrophil migration into mouse peritoneum. Eur. J. Immunol. 24: 3019-3024

M. Lenter and D. Vestweber (1994) The integrin chains β1 and a6 associate with the chaperone calnexin prior to integrin assembly. J. Biol. Chem. 269: 12263 - 12268

M. Lenter, A. Levinovitz, S. Isenmann and D. Vestweber (1994) Monospecific and common glycoprotein ligands for E- and P-selectin on myeloid cells. J. Cell Biol. 125: 471 - 481

1993

M. Lenter, H. Uhlig, A. Hamann, P. Jenö, B. Imhof and D. Vestweber (1993) A monoclonal antibody against an activation epitope on mouse integrin chain β1 blocks adhesion of lymphocytes to the endothelial integrin a6β1. Proc. Natl. Acad. Sci. USA 90: 9051-9055

A. Levinovitz, J. Mühlhoff, S. Isenmann and D. Vestweber (1993) Identification of a glycoprotein ligand for E-selectin on mouse myeloid cells. J. Cell Biol. 121, 449-459 (1993)

M. Hahne, U. Jäger, S. Isenmann, R. Hallmann and D. Vestweber (1993) Five TNF-inducible cell adhesion mechanisms on the surface of mouse endothelioma cells mediate the binding of leukocytes. J. Cell Biol. 121: 655-664

1992

A. Weller, S. Isenmann and D. Vestweber (1992) Cloning of the mouse endothelial selectins: Expression of both E- and P-selectin is inducible by tumor necrosis factor a. J. Biol. Chem. 267: 15176-15183

1990

K.P. Baker, A. Schaniel, D. Vestweber and G. Schatz (1990) A yeast mitochondrial outer membrane protein essential for protein import and cell viability. Nature 348: 605-609

P.E. Scherer, U.C. Krieg, S.T. Hwang, D. Vestweber and G. Schatz (1990) A precursor protein partly translocated into yeast mitochondria is bound to a 70kD mitochondrial stress protein.EMBO J. 9: 4315-4322

1989

D. Vestweber and G. Schatz (1989) Blockage and quantification of mitochondrial protein import sites by an internally crosslinked hybrid precursor protein. Nova acta Leopoldina 61: 409-416

D. Vestweber and G. Schatz (1989) DNA-protein conjugates can enter mitochondria via the protein import pathway. Nature 338: 170-172

D. Vestweber, J. Brunner, A. Baker and G. Schatz (1989) A 42K outer membrane protein is a component of the yeast mitochondrial protein import site. Nature 341: 205-209

1988

D. Vestweber and G. Schatz (1988) Point mutations destabilizing a precursur protein enhance its post-translational import into mitochondria. EMBO J. 7: 1147-1151

D. Vestweber and G. Schatz (1988) Mitochondria can import artificial precursor proteins containing a branched polypeptide chain or a carboxy-terminal stilbene disulfonate J. Cell Biol. 107: 2045-2049

D. Vestweber and G. Schatz (1988) A chimeric mitochondrial precursor protein with internal disulfide bridges blocks import of authentic precursors into mitochondria and allows quantitation of import sites. J. Cell Biol. 107: 2037-2043

1987

M. Ringwald, R. Schuh, D. Vestweber, H. Eistetter, F. Lottspeich, J. Engel, R. Dölz, F. J. Jähnig, J. Epplen, S. Mayer, C. Müller and R. Kemler (1987) The structure of cell adhesion molecule uvomorulin. Insights into the molecular mechanism of calcium dependent cell adhesion. EMBO J. 6: 3647-3653

D. Vestweber, A. Gossler, K. Boller and R. Kemler (1987) Expression and distribution of cell adhesion molecule uvomorulin in mouse preimplantation embryos Dev. Biol. 124: 451-456

1986

R. Schuh, D. Vestweber, I. Riede, U.B. Rosenberg, H. Jäckle and R. Kemler (1986) Molecular cloning of mouse cell adhesion molecule uvomorulin: cDNA contains a B1 related sequence. Proc. Natl. Acad. Sci. USA 83: 1364-1368

1985

D. Vestweber and R. Kemler (1985) Identification of a putative cell adhesion domain of uvomorulin. EMBO J. 4: 3393-3398

D. Vestweber, R. Kemler and P. Ekblom (1985) Cell adhesion molecule uvomorulin during kidney development. Dev. Biol. 112: 213-221

D. Vestweber, C. Ocklind, A. Gossler, P. Odin, B. Öbrink and R. Kemler (1985) Comparison of two cell adhesion molecules, uvomorulin and cell-CAM 105. Exp. Cell Res. 157: 451-461

K. Boller, D. Vestweber and R. Kemler (1985) Cell adhesion molecule uvomorulin is localized in the indermediate junctions of adult intestinal epithelial cells. J. Cell Biol. 100: 327-332

1984

D. Vestweber and R. Kemler (1984) Rabbit antiserum against a purified surface glycoprotein decompacts mouse preimplantation embryos and reacts with specific adult tissues. Exp. Cell Res. 152: 169-178

D. Vestweber and R. Kemler (1984) Some structural and functional aspects of the cell adhesion molecule uvomorulin. Cell Differentiation 15: 269-273