Publications

Selected recent publications

Koester J, Miroshnikova YA, Ghatak S, Chacón-Martínez CA, Morgner J, Li X, Atanassov I, Koch M, Bloch W, Bartusel M, Niessen CM, Rada-Iglesias A, Wickström SA. (2021) Niche stiffening compromises stem cell potential during aging by reducing chromatin accessibility at bivalent promoters. Nat Cell Biol 7, 771-781.

Nava MM, Miroshnikova YA, Biggs LC, Whitefield DB, Metge F, Boucas J, Vihinen H, Jokitalo E, Li X, García Arcos JM, Hoffmann B, Merkel R, Niessen CM, Dahl KN, Wickström SA. (2020) Heterochromatin-driven nuclear softening protects the genome against mechanical stress-induced damage. Cell 181, 800-817 Highlighted by Cell Preview, Faculty of 1000

Kim CS, Ding X, Allmeroth K, Biggs, LC, Kolenc OI, L’Hoest N, Chacón-Martínez CA, Edlich-Muth C, Giavalisco P, Quinn KP, Denzel M, Eming SA, Wickström SA. (2020) Glutamine metabolism controls stem cell fate reversibility and long-term maintenance in the hair follicle. Cell Metabolism 32, 629-642.e8

Miroshnikova YA, Le HQ, Schneider D, Thalheim T, Rübsam M, Bremicker N, Polleux J, Höppner N, Tarantola M, Wang I, Balland M, Niessen CM, Galle J, Wickström SA. (2018). Adhesion forces and cortical tension couple cell proliferation and differentiation to drive epidermal stratification. Nat Cell Biol 20, 69-80. Highlighted by Faculty of 1000

Chacon-Martinez CA, Klose M, Niemann C, Glauche I, Wickström SA. (2017). Hair follicle stem cell cultures reveal self-organizing plasticity of stem cells and their progeny. EMBO J 36, 151-164. Highlighted by EMBOJ News&Views, Faculty of 1000

Le HQ, Ghatak S, Yeung CY, Tellkamp F, Günschmann C, Dieterich C, Yeroslaviz A, Habermann B, Pombo A, Niessen CM, Wickström SA. (2016). Mechanical regulation of transcription controls Polycomb-mediated gene silencing during lineage commitment. Nat Cell Biol 18, 864-875. Highlighted by Nature Reviews Molecular Cell Biology, Faculty of 1000

Morgner J, Ghatak S, Jakobi T, Dieterich C, Aumailley M, Wickström SA. (2015). Integrin-linked kinase regulates the niche of quiescent epidermal stem cells. Nat Commun 6, 8198.

All publications

2021

Maki K, Nava MM, Villeneuve C, Chang M, Furukawa KS, Ushida T, Wickström SA. (2021) Hydrostatic pressure promotes chondrocyte quiescence and progenitor state through heterochromatin remodeling and suppression of replicative stress J Cell Sci 134(2):jcs247643

Jiang C, Javed A, Kaiser L, Nava MM, Zhao D, Brandt DT, Fernandez J, Zhou L, Höß C, Sawmynaden K, Oleksy A, Matthews D, Weinstein LS, Niessen CM, Offermanns S, Wickström SA, Worzfeld T. (2021) Mechanochemical control of epidermal stem cell divisions by B-plexins Nat Commun 12, 1308.

Trela E, Lan Q, Myllymäki S, Villeneuve C, Lindström R, Kumar V, Wickström SA, Mikkola ML. (2021) Cell influx and contractile actomyosin force drive mammary bud growth and invagination. J Cell Biol Aug 2;220(8):e202008062.

Miroshnikova YA, Manet S, Li X, Wickström SA, Faurobert E, Albiges-Rizo C, (2021) Calcium signaling mediates a biphasic mechanoadaptive response of endothelial cells to cyclic mechanical stretch Mol Biol Cell Jun 3; mbcE21030106. doi: 10.1091/mbc.E21-03-0106

Allmeroth K, Kim CS, Annibal A, Pouikli A, Koester J, Derisbourg MJ, Andrés Chacón-Martínez C, Latza C, Antebi A, Tessarz P, Wickström SA, Denzel MS (2021) N1-acetylspermidine is a determinant of hair follicle stem cell fate. J Cell Sci 134(9):jcs252767.

Ylivinkka, I, Wickström SA (2021) BETting agains wound healing. Nat Chem Biol. 585, 355-356.

Villeneuve C, Wickström SA (2021) Shaping the stem cell field. Nat Rev Mol Cell Biol. Feb 10. doi: 10.1038/s41580-021-00347-9.

Tayem R, Niemann C, Pesch M, Morgner J, Niessen CM, Wickström SA, Aumailley M (2021) Laminin 332 is indispensable for homeostatic epidermal differentiation programs. J Invest Dermatol May 6:S0022-202X(21)01215-X

Coulombe P, Wickström SA (2021) A niche above: A novel modality of stem cell regulation in mammalian skin epidermis. Cell Stem Cell. 28, 365-366.

2020

Nava MM, Miroshnikova YA, Biggs LC, Whitefield DB, Metge F, Boucas J, Vihinen H, Jokitalo E, Li X, García Arcos JM, Hoffman B, Merkel R, Niessen CM, Dahl KN, Wickström SA. (2020) Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage. Cell 181, 800-817.

Punovuori K, Wickström SA (2020) How cancer invasion takes place. Nature. 585, 355-356

Dekoninck S, Hannezo E, Sifrim A, Miroshnikova YA, Aragona M, Malfait M, Gargouri S, de Neunheuser C, Dubois C, Voet T, Wickström SA, Simons BD, Blanpain C. (2020) Defining the Design Principles of Skin Epidermis Postnatal Growth. Cell 181, 604-620.

Biggs LC, Kim CS, Miroshnikova YA, Wickström SA. (2020) Mechanical Forces in the Skin: Roles in Tissue Architecture, Stability, and Function. J Invest Dermatol 140, 284-290.

Ding X, Willenborg S, Bloch W, Wickström SA, Wagle P, Brodesser S, Roers A, Jais A, Brüning JC, Hall MN, Rüegg M, Eming SA. (2020) Epidermal mammalian target of rapamycin complex 2 controls lipid synthesis and filaggrin processing in epidermal barrier formation. J Allergy Clin Immunol 145, 283-300.

2019

Miroshnikova YA, Hammesfahr T, Wickström SA. (2019) Cell biology and mechanopathology of laminopathic cardiomyopathies. J Cell Biol 218, 393-394.

Miroshnikova YA, Cohen I, Ezhkova E, Wickström SA. (2019) Epigenetic gene regulation, chromatin structure, and force-induced chromatin remodelling in epidermal development and homeostasis. Curr Opin Genet Dev 55, 46-51.

Ou H-L, Kim CS, Uszkoreit S, Wickström SA, Schumacher B. (2019) Somatic Niche Cells Regulate the CEP-1/p53-Mediated DNA Damage Response in Primordial Germ Cells. Dev Cell 50, 167-183.

2018

Chacon-Martinez CA, Koester J, Wickström SA. (2018). Signaling in the stem cell niche: regulating cell fate, function and plasticity. Development 145, dev165399.

Wickström SA. * and Niessen CM*. (2018). Cell adhesion and mechanics as drivers of tissue organization and differentiation: local cues for large scale organization. Curr Opin Cell Biol 54, 89-97. *Corresponding authors

Nüchel J, Zuk A, Schönborn K, Rabenhorst A, Blumbach K, Wickström SA, Krieg T, Sengle G, Plomann M, and Eckes B. (2018) TGFβ1 is secreted through an unconventional pathway dependent on the autophagic machinery and cytoskeletal regulators. Autophagy 14, 465-486.

Rübsam M, Broussard JA, Wickström SA, Nekrasova O, Green KJ, Niessen CM. (2018). Adherens Junctions and Desmosomes Coordinate Mechanics and Signaling to Orchestrate Tissue Morphogenesis and Function: An Evolutionary Perspective. Cold Spring Harb Perspect Biol 10, a029207.

2017

Rübsam M, Mertz AF, Kubo A, Marg S, Ziegler W, Jungst C, Schauss A, Horsley V, Dufresne E, Amagai M. Wickström SA, and Niessen CM. (2017) E-cadherin integrates EGFR signaling and mechanotransduction to control tissue polarization and skin barrier function. Nat Commun 8, 1250.

Rinschen MM, Grahammer F, Hoppe AK, Kohli P, Hagmann H, Kretz O, Bertsch S, Höhne M, Göbel H, Bartram MP, Gandhirajan RK, Krüger M, Brinkkötter PT, Huber TB, Wickström SA, Benzing T, Schermer B. (2017). YAP-mediated mechanotransduction determines the podocyte's response to injury. Sci Signal 10, eaaf8165.

Elzeneini E, and Wickström SA. (2017). Lipodystrophic laminopathy: Lamin A mutation relaxes chromatin architecture to impair adipogenesis. J Cell Biol 216, 2607-2610.

Miroshnikova YA, Nava MM, and Wickström, SA. (2017) Emerging roles of mechanical forces in chromatin regulation. J Cell Sci 130, 2243-2250.

2016

Krenn PW, Hofbauer SW, Pucher S, Hutterer E, Hinterseer E, Asslaber D, Sternberg C, Neureiter D, Aberger F, Wickström SA, Egle A, Greil R, Hartmann TN. (2016). Integrin-linked kinase is induced by TNFα-NF-κB signals and required for centrosome clustering in chronic lymphocytic leukemia cells. Cancer Res 76, 2186-2196.

2015

Morgner J, Ghatak S, Jakobi T, Dieterich C, Aumailley M, Wickström SA. (2015). Integrin-linked kinase regulates the niche of quiescent epidermal stem cells. Nat Commun 6, 8198.

Rahn E, Petermann P, Their K, Bloch W, Morgner J, Wickström SA, Knebel-Mörsdorf D. (2015). Invasion of Herpes Simplex Virus Type 1 into Murine Epidermis: An Ex Vivo Infection Study, J Invest Dermatol 135, 3009-3016.

Schneider D, and Wickström SA. (2015). Force generation and transmission in keloid fibroblasts: Dissecting the role of mechanosensitive molecules in cell function. Exp Dermatol 8, 574-575.

2014

Schiefermeier N, Scheffler JM, de Araujo MEG, Stasyk T, Yordanov T, Ebner HL, Offterdinger M, Munck S, Hess MW, Wickström SA, Lange A, Wunderlich W, Fässler R, Teis D, Huber LA. (2014). The late endosomal p14/MP1 (Lamtor2/3) complex regulates focal adhesion dynamics during cell migration. J Cell Biol 205, 525-540.

Eckes B, Krieg T, and Wickström SA. (2014). Role of integrin signaling through Integrin-linked kinase (ILK) in skin physiology and pathology. Exp Dermatol 23, 453-456.

2013

Traub S, J, Martino MM, Höning S, Swartz MA, Wickström SA, Hubbell JA, Eming SA. (2013). The promotion of endothelial cell attachment and spreading using FNIII10 fused to VEGF-A165. Biomaterials 34, 5958-5968.

Radovanac K, Morgner J, Schulz JN, Blumbach K, Patterson C, Geiger T, Mann M, Krieg T, Eckes B, Fässler R, Wickström SA. (2013). Stabilization of Integrin-linked kinase by the Hsp90-CHIP axis impacts cellular force generation, migration and the fibrotic response. EMBO J 32, 1409-1424.

Malan D, Elischer A, Hesse M, Wickström SA, Fleischmann BK, Block W. (2013). Deletion of integrin linked kinase in endothelial cells reults in defective RTK signaling caused by caveolin 1 mislocalization. Development 140, 987-995.

Zanivan S, Meves A, Behrendt K, Schoof EM, Neilson LJ, Cox J, Tang HR, Kalna G, van Ree JH, van Deursen JM, Trempus CS, Machesky LM, Linding R, Wickström SA, Fässler R, Mann M. (2013). In vivo SILAC-based proteomics reveals phosphoproteome changes during mouse skin carcinogenesis. Cell Reports 21, 552-66.

Morgner J, and Wickström SA. (2013). The weakest link: A new paradigm for stabilizing the integrin-actin connection. Cell Cycle 12, 2929-2930.

Ghatak, S, Morgner J, and Wickström SA. (2013). ILK: a pseudokinase with a unique function in the integrin-actin linkage. Biochem Soc Trans 41, 995-1001.

2011

Wickström SA,* and Fässler R. (2011). Regulation of membrane traffic by integrin signaling. Trends Cell Biol 21, 266-273. * Corresponding author

Wickström SA,* Radovanac K, and Fässler R. (2011).Genetic analyses of integrin signaling. Cold Spring Harb Perspect Biol 3, a005116. * Corresponding author

Wickström SA*, Lange A, Hess MW, Polleux J, Spatz JP, Krüger M, Pfaller K, Lambacher A, Bloch W, Mann M, Huber LA, Fässler R. (2010). Integrin-linked kinase controls microtubule dynamics required for plasma membrane targeting of caveolae. Dev Cell 19, 574-588. *Corresponding author; Highlighted by Faculty of 1000 and Nature Reviews Molecular Cell Biology

Wickström SA, Masoumi KC, Khochbin S, Fässler R, Massoumi R. (2010). CYLD negatively regulates cell cycle progression by inactivation of HDAC6 and accumulation of acetylated tubulin. EMBO J 29, 131-144.

Wickström SA, Lange A, Montanez E, and Fässler R. (2010). The ILK/PINCH/parvin complex: the kinase is dead, long live the pseudokinase! EMBO J 29, 281-291.

Legate KR*, Wickström SA*, and Fässler R. (2009). Genetic and cell biological analysis of integrin inside-out signaling. Genes Dev 23, 397-418. * Equal contribution

Wickström SA and Fässler R. (2009). Integrins anchor the invasive machinery. Dev Cell 17, 158-160.

Montanez E, Wickström SA, Altstätter J, Chu H, Fässler R. (2009). α-parvin controls vascular mural cell recruitment to vessel wall by regulating RhoA/ROCK signalling. EMBO J 28, 3132 - 3144.

Lange A, Wickström SA, Jakobson M, Zent R, Sainio K, Fässler R. (2009). Integrin-linked kinase is an adaptor with essential functions during mouse development. Nature 461, 1002-1006.

Zanivan S, Gnad F, Wickström SA, Geiger T, Macek B, Cox J, Fässler R, Mann M. (2008). Solid Tumor Proteome and Phosphoproteome Analysis by High Resolution Mass Spectrometry. J Proteome Res 7, 5314–5326.

Wang HV, Chang LW, Brixius K, Wickström SA, Montanez E, Thievessen I, Schwander M, Müller U, Bloch W, Mayer U, Fässler R. (2008). Integrin-linked kinase stabilizes myotendinous junctions and protects muscle from stress-induced damage. J Cell Biol 180, 1037-1049.

Zhao H, Jutila A, Nurminen T, Wickström SA, J, Kinnunen PK. (2005). Binding of endostatin to phosphatidylserine containing membranes and formation of amyloid fibers. Biochemistry 44, 2857-2863.

Wickström SA, Alitalo K, and Keski-Oja J. (2005). Endostatin signalling and regulation of endothelial cell – matrix interactions. Adv Cancer Res 94, 197-229.

Wickström SA and Keski-Oja J. (2005). Degradation products of endothelial basement membranes: their role as tumor suppressor. Duodecim 121, 27-35. (Article in Finnish)

Wickström SA, Alitalo K, Keski-Oja J. (2004). An endostatin-derived peptide interacts with integrins and regulates actin cytoskeleton and migration of endothelial cells. J Biol Chem 279, 20178-20185.

Wickström SA, Alitalo K, Keski-Oja J. (2003). Endostatin associates with lipid rafts and induces actin cytoskeleton reorganization via down regulation of RhoA activity. J Biol Chem 278, 37895-37901.

Wickström SA, Keski-Oja J, and Alitalo K. (2003). Matrix reloaded to circulation hits the tumor target. Cancer Cell 3: 513-514.

Wickström SA, Alitalo K, Keski-Oja J. (2002). Endostatin associates with α₅β₁ integrin and caveolin-1 and activates Src via a tyrosyl phosphatase-dependent pathway in human endothelial cells. Cancer Res 62, 5580-5589.

Wickström SA, Veikkola T, Rehn M, Pihlajaniemi T, Alitalo K, Keski-Oja J. (2001). Endostatin-induced modulation of plasminogen activation with concomitant loss of focal adhesions and actin stress fibers in human endothelial cell cultures. Cancer Res 61, 6511-6516.

Lehti K, Valtanen H, Wickström SA, Lohi J, J. (2001). Regulation of membrane-type-1 matrix metalloproteinase activity by its cytoplasmic domain. J Biol Chem 275, 15006-13.