Publications
Chen R, Fan R, Chen F, Govindasamy N, Brinkmann H, Stehling M, Adams RH, Jeong H-W*, Bedzhov I*, Analyzing embryo dormancy at single-cell resolution reveals dynamic transcriptional responses and activation of integrin-Yap/Taz prosurvival signaling. Cell Stem Cell, 2024
Schumacher S, Fernkorn M, Marten M, Chen R, Kim YS, Bedzhov I, Schröter C. Tissue-intrinsic beta-catenin signals antagonize Nodal-driven anterior visceral endoderm differentiation. Nature Communications, 2024
MacCarthy CM, Wu G, Malik V, Menuchin-Lasowski Y, Velychko T, Keshet G, Fan R, Bedzhov I, Church GM, Jauch R, Cojocaru V, Schöler HR, Velychko S. Highly cooperative chimeric super-SOX induces naive pluripotency across species. Cell Stem Cell, 2024
Hou Y, Nie Z, Velychko S, Bedzhov I, Heising S, Jiang Q, Zhang H, Wu G, Adachi K, Schöler HR. Emerging cooperativity between Oct4 and Sox2 governs the pluripotency network in mouse embryos. bioRxiv, 2023
Govindasamy N, Long H, Trappmann B, Ranga A and Bedzhov I*. 3D biomimetic environment enabling ex utero trophoblast invasion and co-culture of embryos and somatic cells. STAR Protocols, 2023
Ozguldez HO, Govindasamy N, Fan R, Long H, Mildner K, Zeuschner D, Trappmann B, Ranga A and Bedzhov I*. Polarity inversion reorganizes the stem cell compartment of the trophoblast lineage. Cell Reports, 2023
Sathyanarayanan A, Ing-Simmons E, Chen R, Jeong H-W, Ozguldez HO, Fan R, Duethorn B, Kim K-P, Kim YS, Stehling M, Brinkmann H, Schöler HR, Adams RH, Vaquerizas JM and Bedzhov I*. Early developmental plasticity enables the induction of an intermediate extraembryonic cell state. Science Advances, 2022
Kim YS, Fan R, Lith SC, Dicke AK, Drexler HCA, Kremer L, Kuempel-Rink N, Hekking L, Stehling M and Bedzhov I*. Rap1 controls epiblast morphogenesis in sync with the pluripotency states transition. Developmental Cell, 2022
Kim YS and Bedzhov I*. Mechanisms of formation and functions of the early embryonic cavities. Seminars in Cell and Developmental Biology, 2022
Duethorn B, Groll F, Rieger B, Drexler H C A, Brinkmann H, Kremer L, Stehling M, Borowski M-T, Mildner K, Zeuschner D, Zernicka-Goetz M, Stemmler M P, Busch K B, Vaquerizas J M and Bedzhov I* - Lima1 mediates the pluripotency control of membrane dynamics and cellular metabolism. Nature Communications, 2022
Han D, Wu G, Chen R, Drexler HCA, MacCarthy CM, Kim KP, Adachi K, Gerovska D, Mavrommatis L, Bedzhov I, Arauzo-Bravo MJ, Scholer HR, A balanced Oct4 interactome is crucial for maintaining pluripotency. Science Advances, 2022
Eliat F, Sohn R, Renner H, Kagermeier T, Volkery S, Brinkmann H, Kirschnick N, Kiefer F, Grabos M, Becker K, Bedzhov I, Schöler HR, Bruder JM. Tissue clearing may alter emission and absorption properties of common fluorophores. Scientific Reports, 2022
Xu C, Dinh VV, Kruse K, Jeong HW, Watson EC, Adams S, Berkenfeld F, Stehling M, Rasouli SJ, Fan R, Chen R, Bedzhov I, Chen Q, Kato K, Pitulescu ME, Adams RH, Induction of osteogenesis by bone-targeted Notch activation. Elife, 2022
Govindasamy N, Long H, Jeong H-W, Raman R, Özcifci B, Probst S, Arnold SJ, Riehemann K, Ranga A, Adams RH, Trappmann B* and Bedzhov I* - 3D biomimetic platform reveals the first interactions of the embryo and the maternal blood vessels. Developmental Cell, 2021
Salewskij K, Gross-Thebing T, Ing-Simmons E, Duethorn B, Rieger B, Fan R, Chen R, Govindasamy N, Brinkmann H, Kremer L, Kuempel-Rink N, Mildner K, Zeuschner D, Stehling M, Dejosez M, Zwaka TP, Schöler HR, Busch KB, Vaquerizas JM and Bedzhov I*, Ronin governs the metabolic capacity of the embryonic lineage for post-implantation development. EMBO Reports, 2021
Kim Y S, Fan R, Kremer L, Kuempel-Rink N, Mildner K, Zeuschner D, Hekking L, Stehling M, and Bedzhov I*, Deciphering epiblast lumenogenesis reveals proamniotic cavity control of embryo growth and patterning. Science Advances, 2021
Ozguldez HO and Bedzhov I*, In vitro culture of mouse blastocysts to egg cylinder stage via mural trophectoderm excision, Methods in Molecular Biology, 2021
Fan R, Kim, Y S, Wu J., Chen R, Zeuschner D, Mildner K, Adachi K, Wu G, Galatidou S, Li J, Scholer H R, Leidel S A and Bedzhov I *, Wnt/Beta-catenin/Esrrb signalling controls the tissue-scale reorganization and maintenance of the pluripotent lineage during murine embryonic diapause, Nature Communications, 2020
Ozguldez HO, Fan R and Bedzhov I*, Placental gene editing via trophectoderm-specific Tat-Cre/loxP recombination, Development, 2020
Agrawal M, Schwarz P, Giaimo BD, Bedzhov I, Corbacioglu A, Weber D, Gaidzik VI, Jahn N, Rücker FG, Schroeder T, Kindler T, Wattad M, Götze K, Lübbert M, Salwender H, Ringhoffer M, Lange E, Koller E, Thol F, Heuser M, Ganser A, Bullinger L, Paschka P, Döhner H, Geiger H, Borggrefe T, Döhner K, Oswald F. Functional and clinical characterization of the alternatively spliced isoform AML1-ETO9a in adult patients with translocation t(8;21)(q22;q22.1) acute myeloid leukemia (AML), Leukemia, 2020
Govindasamy N & Bedzhov I* – Isolation and culture of peri-implantation and early post-implantation mouse embryos, Methods in Molecular Biology, 2019
Govindasamy N, Duethorn B, Ozgueldez HO, Kim YS, Bedzhov I* - Test-tube embryos - mouse and human development in vitro to blastocyst stage and beyond, Int. J. of Developmental Biology, 2019
Bedzhov I, Bialecka M, Zielinska A, Kosalka J, Antonica F, Thompson AJ, Franze K, Zernicka-Goetz M – Development of the anterior-posterior axis is a self-organising process in the absence of maternal cues in the mouse embryo. Cell Research, 2015
Bedzhov I, Zernicka-Goetz M – Cell death and morphogenesis during early mouse development: are they interconnected? Bioessays, 2015
Bedzhov I, Stemmler MP – Applying the Proximity Ligation Assay (PLA) to mouse preimplantation embryos for identifying protein-protein interactions in situ. Methods in Molecular Biology, 2015
Bedzhov I, Zernicka-Goetz M – Self-organizing properties of mouse pluripotent cells initiate morphogenesis upon implantation. Cell, 2014
Bedzhov I, Bialecka M, Leung CY, Zernicka-Goetz M – In vitro culture of mouse blastocysts beyond the implantation stages. Nature Protocols, 2014
Bedzhov I, Leung CY, Graham S, Zernicka-Goetz M – Developmental plasticity, cell fate specification and morphogenesis in the early mouse embryo, Philosophical Transactions B, 2014
Bedzhov I, Alotaibi H, Basilicata MF, Ahlborn K, Liszewska E, Brabletz T, Stemmler MP – Adhesion, but not a specific cadherin code, is indispensable for ES cell and induced pluripotency. Stem Cell Research, 2013
Bedzhov I, Liszewska E, Kanzler B, Stemmler MP – Igf1r signaling is indispensable for preimplantation development and is activated via a novel function of E-cadherin. PLoS Genetics, 2012
Stemmler MP, Bedzhov I – A Cdh1HA knock-in allele rescues the Cdh1−/− phenotype but shows essential Cdh1 function during placentation. Developmental Dynamics, 2010
Borissova, T. Hvarleva, I. Bedzhov, V. Kondakova, A. Atanassov, I. Atanassov – Agrobacterium - mediated transformation of secondary somatic embryos from Rosa hybrida L. and recovery of transgenic plants. Biotech. & Biotech Eq. 2005
Patents
Generation of trophectoderm-like cells and assembly of trophectoderm-like vesicles and synthetic embryoids, 2020, EP20181414.2
Media and methods for culturing embryos and stem cells. 2015, WO2015022541